There are actually two questions here.
1) Is Anwar’s political career over?
2) Will the reformasi movement, the quest for reforms, be stalled or derailed?
Personally, I believe the answer to both questions is No.
An Anwar behind bars will only grow in stature and become a rallying point, much the same way as Aung San Suu Kyi and Mandela did.
As for the reformasi movement, we have come a long way so far – Malaysians have tasted the New Politics and many want the country to move in that direction – so it is unlikely that reactionary forces will be able to reverse those gains without incurring considerable political cost.
What do you think?